A dual-mode surface display system for the maturation and production of monoclonal antibodies in glyco-engineered Pichia pastoris.

A dual-mode surface display system for the maturation and production of monoclonal antibodies in glyco-engineered Pichia pastoris.

State-of-the-art monoclonal antibody (mAb) discovery methods that utilize surface display techniques in prokaryotic and eukaryotic cells require multiple steps of reformatting and switching of hosts to transition from display to expression. This results in a separation between antibody affinity matu...

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Bibliographic Details
Main Authors: Hussam H Shaheen, Bianka Prinz, Ming-Tang Chen, Tej Pavoor, Song Lin, Nga Rewa Houston-Cummings, Renee Moore, Terrance A Stadheim, Dongxing Zha
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3707868?pdf=render

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