Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes

Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes

Modifying the length of the Huntington's disease (HD) CAG repeat, the major determinant of age of disease onset, is an attractive therapeutic approach. To explore this we are investigating mechanisms of intergenerational and somatic HD CAG repeat instability. Here, we have crossed HD CAG knock-...

Full description

Bibliographic Details
Main Authors: Ella Dragileva, Audrey Hendricks, Allison Teed, Tammy Gillis, Edith T. Lopez, Errol C. Friedberg, Raju Kucherlapati, Winfried Edelmann, Kathryn L. Lunetta, Marcy E. MacDonald, Vanessa C. Wheeler
Format: Article
Language:English
Published: Elsevier 2009-01-01
Series:Neurobiology of Disease
Subjects:
Huntington's disease
Trinucleotide
Instability
Repeat
Striatum
Repair
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108002234

Internet

http://www.sciencedirect.com/science/article/pii/S0969996108002234

Similar Items