TSPAN12 Is a Norrin Co-receptor that Amplifies Frizzled4 Ligand Selectivity and Signaling

TSPAN12 Is a Norrin Co-receptor that Amplifies Frizzled4 Ligand Selectivity and Signaling

Accessory proteins in Frizzled (FZD) receptor complexes are thought to determine ligand selectivity and signaling amplitude. Genetic evidence indicates that specific combinations of accessory proteins and ligands mediate vascular β-catenin signaling in different CNS structures. In the retina, the te...

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Bibliographic Details
Main Authors: Maria B. Lai, Chi Zhang, Jianli Shi, Verity Johnson, Lavan Khandan, John McVey, Michael W. Klymkowsky, Zhe Chen, Harald J. Junge
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Cell Reports
Subjects:
FEVR
FZD4
TSPAN12
Norrin
NDP
tetraspanin
retina
angiogenesis
blood-retina barrier
blood-brain barrier
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717307817

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http://www.sciencedirect.com/science/article/pii/S2211124717307817

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