In vivo AAV delivery of glutathione reductase gene attenuates anti-aging gene klotho deficiency-induced kidney damage

In vivo AAV delivery of glutathione reductase gene attenuates anti-aging gene klotho deficiency-induced kidney damage

Objective: Klotho is an aging-suppressor gene which leads to accelerated aging when disrupted. This study was designed to investigate whether glutathione reductase (GR), a critical intracellular antioxidant enzyme, is involved in the pathogenesis of kidney damages associated with accelerated aging i...

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Bibliographic Details
Main Authors: Diansa Gao, Shirley Wang, Yi Lin, Zhongjie Sun
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Redox Biology
Subjects:
Klotho
Glutathione reductase
GSH/GSSG ratio
Kidney damage
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720308971

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