THE INTERACTION BETWEEN SOME VEGETAL POLYPHENOLIC EXTRACTS AND CHOLESTEROL AT THE LEVEL OF THE CELLULAR MEMBRANE

THE INTERACTION BETWEEN SOME VEGETAL POLYPHENOLIC EXTRACTS AND CHOLESTEROL AT THE LEVEL OF THE CELLULAR MEMBRANE

“In vitro” treatment of the fibers of sartoruis muscle of frog (Rana ridibunda, Pall) with 0,1 mM cholesterol causes on increase of the membranary resting potential (hyperpolarization), seen as irreversible on washing of the preparations with Ringer physiological solution without cholesterol. The po...

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Main Authors: Pincu Rotinberg, Cosmin Mihai, Daniela Gherghel
Format: Article
Language:English
Published: "Alexandru Ioan Cuza" University of Iași 2007-08-01
Series:Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara
Online Access:http://www.gbm.bio.uaic.ro/index.php/gbm/article/view/393
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spelling doaj-aefe8e3f5e5e42e0a7762b7329de06dd2020-11-24T23:54:57Zeng"Alexandru Ioan Cuza" University of IașiAnalele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara 1582-35712007-08-0181THE INTERACTION BETWEEN SOME VEGETAL POLYPHENOLIC EXTRACTS AND CHOLESTEROL AT THE LEVEL OF THE CELLULAR MEMBRANEPincu RotinbergCosmin MihaiDaniela Gherghel“In vitro” treatment of the fibers of sartoruis muscle of frog (Rana ridibunda, Pall) with 0,1 mM cholesterol causes on increase of the membranary resting potential (hyperpolarization), seen as irreversible on washing of the preparations with Ringer physiological solution without cholesterol. The polyphenolic extracts from bilberry (Vaccinum sp.) fruits, red peony (Poeonia sp.) flowers, black grapes and pink flowers of Hibiscus sp. (2 mg % active substance) remove the cholesterol deposited in the structure of the cellular membranes, thus re-establishing the membranary properties and the redox potential (rH) affected by cholesterol. Such effects are similar to those induced by similarine – a polyphenolic product, and by chlophenate – a drug recommended in therapeutics. The results obtained evidence the properties of the pholyphenolic extracts, as both normalizing agents of the cholesterol proportion from biomembranes and redox modulators, which recommends them for possible pharmacological utilization.http://www.gbm.bio.uaic.ro/index.php/gbm/article/view/393
collection DOAJ
language English
format Article
sources DOAJ
author Pincu Rotinberg
Cosmin Mihai
Daniela Gherghel
spellingShingle Pincu Rotinberg
Cosmin Mihai
Daniela Gherghel
THE INTERACTION BETWEEN SOME VEGETAL POLYPHENOLIC EXTRACTS AND CHOLESTEROL AT THE LEVEL OF THE CELLULAR MEMBRANE
Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara
author_facet Pincu Rotinberg
Cosmin Mihai
Daniela Gherghel
author_sort Pincu Rotinberg
title THE INTERACTION BETWEEN SOME VEGETAL POLYPHENOLIC EXTRACTS AND CHOLESTEROL AT THE LEVEL OF THE CELLULAR MEMBRANE
title_short THE INTERACTION BETWEEN SOME VEGETAL POLYPHENOLIC EXTRACTS AND CHOLESTEROL AT THE LEVEL OF THE CELLULAR MEMBRANE
title_full THE INTERACTION BETWEEN SOME VEGETAL POLYPHENOLIC EXTRACTS AND CHOLESTEROL AT THE LEVEL OF THE CELLULAR MEMBRANE
title_fullStr THE INTERACTION BETWEEN SOME VEGETAL POLYPHENOLIC EXTRACTS AND CHOLESTEROL AT THE LEVEL OF THE CELLULAR MEMBRANE
title_full_unstemmed THE INTERACTION BETWEEN SOME VEGETAL POLYPHENOLIC EXTRACTS AND CHOLESTEROL AT THE LEVEL OF THE CELLULAR MEMBRANE
title_sort interaction between some vegetal polyphenolic extracts and cholesterol at the level of the cellular membrane
publisher "Alexandru Ioan Cuza" University of Iași
series Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara
issn 1582-3571
publishDate 2007-08-01
description “In vitro” treatment of the fibers of sartoruis muscle of frog (Rana ridibunda, Pall) with 0,1 mM cholesterol causes on increase of the membranary resting potential (hyperpolarization), seen as irreversible on washing of the preparations with Ringer physiological solution without cholesterol. The polyphenolic extracts from bilberry (Vaccinum sp.) fruits, red peony (Poeonia sp.) flowers, black grapes and pink flowers of Hibiscus sp. (2 mg % active substance) remove the cholesterol deposited in the structure of the cellular membranes, thus re-establishing the membranary properties and the redox potential (rH) affected by cholesterol. Such effects are similar to those induced by similarine – a polyphenolic product, and by chlophenate – a drug recommended in therapeutics. The results obtained evidence the properties of the pholyphenolic extracts, as both normalizing agents of the cholesterol proportion from biomembranes and redox modulators, which recommends them for possible pharmacological utilization.
url http://www.gbm.bio.uaic.ro/index.php/gbm/article/view/393
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