Message and protein-level elevation of tumor necrosis factor α (TNFα) and TNFα-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis

Message and protein-level elevation of tumor necrosis factor α (TNFα) and TNFα-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis

Recent data indicate that certain pro-inflammatory cytokines are transcriptionally upregulated in the spinal cords of G93A-SOD1 mice, a model of amyotrophic lateral sclerosis (ALS). We previously showed that the receptor for tumor necrosis factor α (TNF-R1) was notably elevated at late presymptomati...

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Bibliographic Details
Main Authors: Kenneth Hensley, Joe Fedynyshyn, Scott Ferrell, Robert A Floyd, Brian Gordon, Paula Grammas, Ladan Hamdheydari, Molina Mhatre, Shenyun Mou, Quentin N Pye, Charles Stewart, Melinda West, Stuart West, Kelly S Williamson
Format: Article
Language:English
Published: Elsevier 2003-10-01
Series:Neurobiology of Disease
Subjects:
Microglia
Amyotrophic lateral sclerosis
Neuroinflammation
Tumor necrosis factor
Cytokines
Chemokines
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103000871

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