Anti-M antibodies: Biphasic (reactive at room temperature and at 37°C): A case series
Anti-M antibody, which is not reactive at 37°C, is not clinically significant. Reports of clinically significant anti-M antibodies causing hemolytic disease of the fetus and the newborn (HDFN) and delayed hemolytic transfusion reaction (DHTR) are available. We report 13 cases of anti-M antibodies re...
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doaj-aef1eccab637487bbb612129934c7e792020-11-24T22:32:37ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652016-01-0110215916010.4103/0973-6247.172181Anti-M antibodies: Biphasic (reactive at room temperature and at 37°C): A case seriesSiddhi P ShahSangeeta M KalgutkarRajesh B SawantAnand S DeshpandeAnti-M antibody, which is not reactive at 37°C, is not clinically significant. Reports of clinically significant anti-M antibodies causing hemolytic disease of the fetus and the newborn (HDFN) and delayed hemolytic transfusion reaction (DHTR) are available. We report 13 cases of anti-M antibodies reactive at room temperature (RT) and at 37°C. These were found in patients of varied age groups (11 months to 85 years) with varied clinical diagnosis. All the female patients were multigravida. In all cases, antibody screening was positive at RT as well as at the indirect antiglobulin test (IAT) phase. Providing “M”-antigen negative transfusions is the best therapy in this situation. Provision of red blood cell (RBC) antigen phenotyped donor registry shall ensure quick provision of antigen-negative blood for transfusion in emergency situations.http://www.ajts.org/article.asp?issn=0973-6247;year=2016;volume=10;issue=2;spage=159;epage=160;aulast=ShahAnti-M antibodybiphasicclinically significantantigen-negative blood |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Siddhi P Shah Sangeeta M Kalgutkar Rajesh B Sawant Anand S Deshpande |
spellingShingle |
Siddhi P Shah Sangeeta M Kalgutkar Rajesh B Sawant Anand S Deshpande Anti-M antibodies: Biphasic (reactive at room temperature and at 37°C): A case series Asian Journal of Transfusion Science Anti-M antibody biphasic clinically significant antigen-negative blood |
author_facet |
Siddhi P Shah Sangeeta M Kalgutkar Rajesh B Sawant Anand S Deshpande |
author_sort |
Siddhi P Shah |
title |
Anti-M antibodies: Biphasic (reactive at room temperature and at 37°C): A case series |
title_short |
Anti-M antibodies: Biphasic (reactive at room temperature and at 37°C): A case series |
title_full |
Anti-M antibodies: Biphasic (reactive at room temperature and at 37°C): A case series |
title_fullStr |
Anti-M antibodies: Biphasic (reactive at room temperature and at 37°C): A case series |
title_full_unstemmed |
Anti-M antibodies: Biphasic (reactive at room temperature and at 37°C): A case series |
title_sort |
anti-m antibodies: biphasic (reactive at room temperature and at 37°c): a case series |
publisher |
Wolters Kluwer Medknow Publications |
series |
Asian Journal of Transfusion Science |
issn |
0973-6247 1998-3565 |
publishDate |
2016-01-01 |
description |
Anti-M antibody, which is not reactive at 37°C, is not clinically significant. Reports of clinically significant anti-M antibodies causing hemolytic disease of the fetus and the newborn (HDFN) and delayed hemolytic transfusion reaction (DHTR) are available. We report 13 cases of anti-M antibodies reactive at room temperature (RT) and at 37°C. These were found in patients of varied age groups (11 months to 85 years) with varied clinical diagnosis. All the female patients were multigravida. In all cases, antibody screening was positive at RT as well as at the indirect antiglobulin test (IAT) phase. Providing “M”-antigen negative transfusions is the best therapy in this situation. Provision of red blood cell (RBC) antigen phenotyped donor registry shall ensure quick provision of antigen-negative blood for transfusion in emergency situations. |
topic |
Anti-M antibody biphasic clinically significant antigen-negative blood |
url |
http://www.ajts.org/article.asp?issn=0973-6247;year=2016;volume=10;issue=2;spage=159;epage=160;aulast=Shah |
work_keys_str_mv |
AT siddhipshah antimantibodiesbiphasicreactiveatroomtemperatureandat37cacaseseries AT sangeetamkalgutkar antimantibodiesbiphasicreactiveatroomtemperatureandat37cacaseseries AT rajeshbsawant antimantibodiesbiphasicreactiveatroomtemperatureandat37cacaseseries AT anandsdeshpande antimantibodiesbiphasicreactiveatroomtemperatureandat37cacaseseries |
_version_ |
1725733246834049024 |