Anti-M antibodies: Biphasic (reactive at room temperature and at 37°C): A case series

Anti-M antibody, which is not reactive at 37°C, is not clinically significant. Reports of clinically significant anti-M antibodies causing hemolytic disease of the fetus and the newborn (HDFN) and delayed hemolytic transfusion reaction (DHTR) are available. We report 13 cases of anti-M antibodies re...

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Main Authors: Siddhi P Shah, Sangeeta M Kalgutkar, Rajesh B Sawant, Anand S Deshpande
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2016-01-01
Series:Asian Journal of Transfusion Science
Subjects:
Online Access:http://www.ajts.org/article.asp?issn=0973-6247;year=2016;volume=10;issue=2;spage=159;epage=160;aulast=Shah
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spelling doaj-aef1eccab637487bbb612129934c7e792020-11-24T22:32:37ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652016-01-0110215916010.4103/0973-6247.172181Anti-M antibodies: Biphasic (reactive at room temperature and at 37°C): A case seriesSiddhi P ShahSangeeta M KalgutkarRajesh B SawantAnand S DeshpandeAnti-M antibody, which is not reactive at 37°C, is not clinically significant. Reports of clinically significant anti-M antibodies causing hemolytic disease of the fetus and the newborn (HDFN) and delayed hemolytic transfusion reaction (DHTR) are available. We report 13 cases of anti-M antibodies reactive at room temperature (RT) and at 37°C. These were found in patients of varied age groups (11 months to 85 years) with varied clinical diagnosis. All the female patients were multigravida. In all cases, antibody screening was positive at RT as well as at the indirect antiglobulin test (IAT) phase. Providing “M”-antigen negative transfusions is the best therapy in this situation. Provision of red blood cell (RBC) antigen phenotyped donor registry shall ensure quick provision of antigen-negative blood for transfusion in emergency situations.http://www.ajts.org/article.asp?issn=0973-6247;year=2016;volume=10;issue=2;spage=159;epage=160;aulast=ShahAnti-M antibodybiphasicclinically significantantigen-negative blood
collection DOAJ
language English
format Article
sources DOAJ
author Siddhi P Shah
Sangeeta M Kalgutkar
Rajesh B Sawant
Anand S Deshpande
spellingShingle Siddhi P Shah
Sangeeta M Kalgutkar
Rajesh B Sawant
Anand S Deshpande
Anti-M antibodies: Biphasic (reactive at room temperature and at 37°C): A case series
Asian Journal of Transfusion Science
Anti-M antibody
biphasic
clinically significant
antigen-negative blood
author_facet Siddhi P Shah
Sangeeta M Kalgutkar
Rajesh B Sawant
Anand S Deshpande
author_sort Siddhi P Shah
title Anti-M antibodies: Biphasic (reactive at room temperature and at 37°C): A case series
title_short Anti-M antibodies: Biphasic (reactive at room temperature and at 37°C): A case series
title_full Anti-M antibodies: Biphasic (reactive at room temperature and at 37°C): A case series
title_fullStr Anti-M antibodies: Biphasic (reactive at room temperature and at 37°C): A case series
title_full_unstemmed Anti-M antibodies: Biphasic (reactive at room temperature and at 37°C): A case series
title_sort anti-m antibodies: biphasic (reactive at room temperature and at 37°c): a case series
publisher Wolters Kluwer Medknow Publications
series Asian Journal of Transfusion Science
issn 0973-6247
1998-3565
publishDate 2016-01-01
description Anti-M antibody, which is not reactive at 37°C, is not clinically significant. Reports of clinically significant anti-M antibodies causing hemolytic disease of the fetus and the newborn (HDFN) and delayed hemolytic transfusion reaction (DHTR) are available. We report 13 cases of anti-M antibodies reactive at room temperature (RT) and at 37°C. These were found in patients of varied age groups (11 months to 85 years) with varied clinical diagnosis. All the female patients were multigravida. In all cases, antibody screening was positive at RT as well as at the indirect antiglobulin test (IAT) phase. Providing “M”-antigen negative transfusions is the best therapy in this situation. Provision of red blood cell (RBC) antigen phenotyped donor registry shall ensure quick provision of antigen-negative blood for transfusion in emergency situations.
topic Anti-M antibody
biphasic
clinically significant
antigen-negative blood
url http://www.ajts.org/article.asp?issn=0973-6247;year=2016;volume=10;issue=2;spage=159;epage=160;aulast=Shah
work_keys_str_mv AT siddhipshah antimantibodiesbiphasicreactiveatroomtemperatureandat37cacaseseries
AT sangeetamkalgutkar antimantibodiesbiphasicreactiveatroomtemperatureandat37cacaseseries
AT rajeshbsawant antimantibodiesbiphasicreactiveatroomtemperatureandat37cacaseseries
AT anandsdeshpande antimantibodiesbiphasicreactiveatroomtemperatureandat37cacaseseries
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