Musim Hujan sebagai Faktor Risiko Kambuh pada Anak Penderita Sindrom Nefrotik Sensitif Steroid

• Main Authors: Arief Budiman, Dany Hilmanto, Herry Garna
• Format: Article
• Language: English
• Published: Universitas Padjajaran 2011-09-01
• Series: Majalah Kedokteran Bandung
• Subjects: Rainy season; relapse; steroid-sensitive nephrotic syndrome
• Online Access: http://journal.fk.unpad.ac.id/index.php/mkb/article/view/55
• ISSN: 0126-074X; 2338-6223

Relapse were common in children with steroid-sensitive nephrotic syndrome (SSNS). Risks of relapse were age at onset, atopic history, acute viral respiratory tract infection (ARI), and genetic. Releasing of interleukin is associated with relapse mechanism in nephrotic syndrome and may be precipitated by high humidity and low temperature as in rainy season. The aim of this study was to determine rainy season as the risk factor of relapse in SSNS. Other risk factors such as ARI and atopic history were also included. This cohort prospective study was conducted of relapsing SSNS patients who fulfilled the criteria of International Study of Kidney Diseases in Children (ISKDC), aged 1−14 years. We recorded time of relapse in rainy season (October 2005–March 2006) and dry season (April–September 2006). Statistical analysis by McNemar and for ARI and atopic history by logistic multivariable regression. From statistical calculation minimal samples were 35. A total of 43 subjects (26 boys and 17 girls) fulfilled the inclusions criteria. Of these subjects, 26 relapsed in rainy season and 7 in dry seasons (X2=9.818, p=0.002, RR=3.71, 95% CI 2.6−9.8). Multivariable analysis with logistic regression revealed that ARI and atopic history had no association with relapses in both seasons (p>0.05). We conclude that rainy season is the risk factor for relapse of SSNS.