Enhancement of ascomycin production via a combination of atmospheric and room temperature plasma mutagenesis in Streptomyces hygroscopicus and medium optimization

Enhancement of ascomycin production via a combination of atmospheric and room temperature plasma mutagenesis in Streptomyces hygroscopicus and medium optimization

Abstract Ascomycin, a key intermediate for chemical synthesis of immunosuppressive drug pimecrolimus, is produced by Streptomyces hygroscopicus var. ascomyceticus. In order to improve the strain production, the original S. hygroscopicus ATCC 14891 strain was treated here with atmospheric and room te...

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Bibliographic Details
Main Authors: Zhituo Yu, Xiaofang Shen, Yuanjie Wu, Songbai Yang, Dianwen Ju, Shaoxin Chen
Format: Article
Language:English
Published: SpringerOpen 2019-02-01
Series:AMB Express
Subjects:
Streptomyces hygroscopicus
Ascomycin
Atmospheric and room temperature plasma
Response surface methodology
Medium optimization
Online Access:http://link.springer.com/article/10.1186/s13568-019-0749-x

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http://link.springer.com/article/10.1186/s13568-019-0749-x

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