The end of the line? A case of drug resistance to third-line antiretroviral therapy

The end of the line? A case of drug resistance to third-line antiretroviral therapy

HIV drug resistance has been described in all antiretroviral drug classes and threatens the long-term success of HIV treatment. Here, we describe the first reported case of acquired resistance to the integrase strand transfer inhibitors in South Africa. This case illustrates the dilemma of treatment...

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Bibliographic Details
Main Authors: Theresa M. Rossouw, Sonia Hitchcock, Mariëtte Botes
Format: Article
Language:English
Published: AOSIS 2016-05-01
Series:Southern African Journal of HIV Medicine
Subjects:
HIV drug resistance
third line
Online Access:https://sajhivmed.org.za/index.php/hivmed/article/view/454
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spelling doaj-aee88417778446969bb1bb05b86d19c22020-11-25T00:36:57ZengAOSISSouthern African Journal of HIV Medicine1608-96932078-67512016-05-01171e1e310.4102/sajhivmed.v17i1.454528The end of the line? A case of drug resistance to third-line antiretroviral therapyTheresa M. Rossouw0Sonia Hitchcock1Mariëtte Botes2Department of Immunology, University of PretoriaDepartment of Family Medicine, University of Pretoria, South Africa; Kalafong Provincial Tertiary Hospital, South AfricaMuelmed Hospital, PretoriaHIV drug resistance has been described in all antiretroviral drug classes and threatens the long-term success of HIV treatment. Here, we describe the first reported case of acquired resistance to the integrase strand transfer inhibitors in South Africa. This case illustrates the dilemma of treatment in the context of inadequate adherence and poor psychosocial support and highlights the potential risk of transmission of multidrug-resistant virus. Keywords: HIV drug resistance; third linehttps://sajhivmed.org.za/index.php/hivmed/article/view/454HIV drug resistancethird line
collection DOAJ
language English
format Article
sources DOAJ
author Theresa M. Rossouw
Sonia Hitchcock
Mariëtte Botes
spellingShingle Theresa M. Rossouw
Sonia Hitchcock
Mariëtte Botes
The end of the line? A case of drug resistance to third-line antiretroviral therapy
Southern African Journal of HIV Medicine
HIV drug resistance
third line
author_facet Theresa M. Rossouw
Sonia Hitchcock
Mariëtte Botes
author_sort Theresa M. Rossouw
title The end of the line? A case of drug resistance to third-line antiretroviral therapy
title_short The end of the line? A case of drug resistance to third-line antiretroviral therapy
title_full The end of the line? A case of drug resistance to third-line antiretroviral therapy
title_fullStr The end of the line? A case of drug resistance to third-line antiretroviral therapy
title_full_unstemmed The end of the line? A case of drug resistance to third-line antiretroviral therapy
title_sort end of the line? a case of drug resistance to third-line antiretroviral therapy
publisher AOSIS
series Southern African Journal of HIV Medicine
issn 1608-9693
2078-6751
publishDate 2016-05-01
description HIV drug resistance has been described in all antiretroviral drug classes and threatens the long-term success of HIV treatment. Here, we describe the first reported case of acquired resistance to the integrase strand transfer inhibitors in South Africa. This case illustrates the dilemma of treatment in the context of inadequate adherence and poor psychosocial support and highlights the potential risk of transmission of multidrug-resistant virus. Keywords: HIV drug resistance; third line
topic HIV drug resistance
third line
url https://sajhivmed.org.za/index.php/hivmed/article/view/454
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AT theresamrossouw endofthelineacaseofdrugresistancetothirdlineantiretroviraltherapy
AT soniahitchcock endofthelineacaseofdrugresistancetothirdlineantiretroviraltherapy
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