Pseudopterosin and <i>O</i>-Methyltylophorinidine Suppress Cell Growth in a 3D Spheroid Co-Culture Model of Pancreatic Ductal Adenocarcinoma

Pseudopterosin and <i>O</i>-Methyltylophorinidine Suppress Cell Growth in a 3D Spheroid Co-Culture Model of Pancreatic Ductal Adenocarcinoma

Current therapies for treating pancreatic ductal adenocarcinoma (PDAC) are largely ineffective, with the desmoplastic environment established within these tumors being considered a central issue. We established a 3D spheroid co-culture in vitro model using a PDAC cell line (either PANC-1 or Capan-2)...

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Bibliographic Details
Main Authors: Bailu Xie, Jan Hänsel, Vanessa Mundorf, Janina Betz, Irene Reimche, Mert Erkan, Ibrahim Büdeyri, Anne Gesell, Russell G. Kerr, Ni Putu Ariantari, Haiqian Yu, Peter Proksch, Nicole Teusch, Randall J. Mrsny
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Bioengineering
Subjects:
3D co-culture
spheroid
stellate cells
PDAC
pancreatic ductal adenocarcinoma
tumor microenvironment
Online Access:https://www.mdpi.com/2306-5354/7/2/57

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