Spirocyclic Motifs in Natural Products

Spirocyclic Motifs in Natural Products

Spirocyclic motifs are emerging privileged structures for drug discovery. They are also omnipresent in the natural products domain. However, until today, no attempt to analyze the structural diversity of various spirocyclic motifs occurring in natural products and their relative populations with uni...

Full description

Bibliographic Details
Main Authors:	Evgeny Chupakhin, Olga Babich, Alexander Prosekov, Lyudmila Asyakina, Mikhail Krasavin
Format:	Article
Language:	English
Published:	MDPI AG 2019-11-01
Series:	Molecules
Subjects:	natural products spirocycles chemical diversity biological activity privileged structures
Online Access:	https://www.mdpi.com/1420-3049/24/22/4165

Similar Items

Synthesis of spirocyclic scaffolds using hypervalent iodine reagents
by: Fateh V. Singh, et al.
Published: (2018-07-01)

New cyclic and spirocyclic aminosilanes
by: Herbig Marcus, et al.
Published: (2021-04-01)

Energetic Tuning in Spirocyclic Conjugated Polymers
by: Hugo Bronstein, et al.
Published: (2016-01-01)

Stable Spirocyclic Meisenheimer Complexes
by: Gonzalo Guirado, et al.
Published: (2008-06-01)

Accessing fused and spirocyclic ring formations via carbon - carbon bond activation
by: Savage, Nikolas Alexander
Published: (2014)

An Efficient Synthesis of a Spirocyclic Oxindole Analogue
by: A. Mendonca, et al.
Published: (2006-09-01)

Spirocyclic Drimanes from the Marine Fungus Stachybotrys sp. Strain MF347
by: Bin Wu, et al.
Published: (2014-04-01)

Recent Progress in Small Spirocyclic, Xanthene-Based Fluorescent Probes
by: Sascha G. Keller, et al.
Published: (2020-12-01)

Fe-catalyzed Decarbonylative Alkylative Spirocyclization of <i>N</i>-Arylcinnamamides: Access to Alkylated 1-Azaspirocyclohexadienones
by: Xiang Peng, et al.
Published: (2020-01-01)

Spirocyclic Nitroxides as Versatile Tools in Modern Natural Sciences: From Synthesis to Applications. Part I. Old and New Synthetic Approaches to Spirocyclic Nitroxyl Radicals
by: Elena V. Zaytseva, et al.
Published: (2021-01-01)

Synthesis of a Novel Spirocyclic Inflatable Flame Retardant and Its Application in Epoxy Composites
by: Kunpeng Song, et al.
Published: (2020-10-01)

Fluorescent “Turn-Off” Detection of Fluoride and Cyanide Ions Using Zwitterionic Spirocyclic Meisenheimer Compounds
by: Marina Benet, et al.
Published: (2017-10-01)

Leishmanicidal Evaluation of Tetrahydroprotoberberine and Spirocyclic Erythrina-Alkaloids
by: Daniel R. Callejon, et al.
Published: (2014-05-01)

Tributylphosphane-promoted [3 + 2] annulation of 3-hydroxyoxindoles with acrylates: Synthesis of spirocyclic oxindole-lactones
by: Qiaomei Jin, et al.
Published: (2018-01-01)

Effects of a Macromolecule Spirocyclic Inflatable Flame Retardant on the Thermal and Flame Retardant Properties of Epoxy Resin
by: Kunpeng Song, et al.
Published: (2020-01-01)

Synthesis and Cytotoxicity Evaluation of Spirocyclic Bromotyrosine Clavatadine C Analogs
by: Piyush A. Patel, et al.
Published: (2021-07-01)

Degradable Spirocyclic Polyacetal-Based Core-Amphiphilic Assemblies for Encapsulation and Release of Hydrophobic Cargo
by: Brandon Andrade-Gagnon, et al.
Published: (2021-01-01)

One-Pot Two-Step Organocatalytic Asymmetric Synthesis of Spirocyclic Piperidones via Wolff Rearrangement–Amidation–Michael–Hemiaminalization Sequence
by: Yanqing Liu, et al.
Published: (2017-02-01)

Asymmetric Synthesis of Spirocyclic 2-Benzopyrans for Positron Emission Tomography of σ1 Receptors in the Brain
by: Katharina Holl, et al.
Published: (2014-01-01)

Organocatalytic, Asymmetric [2+2+2] Annulation to Construct Six-Membered Spirocyclic Oxindoles with Six Continuous Stereogenic Centers
by: Zhi-Long Li, et al.
Published: (2016-04-01)

A construction of 4,4-spirocyclic γ-lactams by tandem radical cyclization with carbon monoxide
by: Mitsuhiro Ueda, et al.
Published: (2013-07-01)

Three Pairs of New Spirocyclic Alkaloid Enantiomers From the Marine-Derived Fungus Eurotium sp. SCSIO F452
by: Weimao Zhong, et al.
Published: (2019-05-01)

Cancer wars: Natural products strike back
by: Christine eBasmadjian, et al.
Published: (2014-05-01)

(R,R/S,S)-9-Benzyl-3-methyl-7-phenyl-1,6-dioxa-3,9-diazaspiro[4.4]nonane-2,8-dione
by: Craig M. Forsyth, et al.
Published: (2019-04-01)

Crystal structure of dimethyl-1κ2C-bis(μ-4-methylphenolato-1:2κ2O:O)(N,N,N′,N′-tetramethylethylenediamine-2κ2N,N′)indium(III)lithium(I)
by: Glen G. Briand, et al.
Published: (2015-12-01)

<em>tert</em>-Butyl 1-(Furan-2-yl)-4-oxo-2,3,7-triazaspiro[4.5]dec-1-ene-7-carboxylate
by: Balladka Kunhanna Sarojini, et al.
Published: (2012-05-01)

<em>N</em>-(3,4-Dimethoxyphenyl)-4-oxo-2,3,7-triazaspiro[4.5]dec-1-ene-1-carboxamide Hydrochloride
by: Seranthimata Samshuddin, et al.
Published: (2012-08-01)

A Brief Overview of Two Major Strategies in Diversity-Oriented Synthesis: Build/Couple/Pair and Ring-Distortion
by: Sihyeong Yi, et al.
Published: (2018-10-01)

Enantioselective synthesis of (+)-polyzonimine, defensive monoterpene alkaloid produced by a milliped Polyzonium rosalbum, and determination of its S absolute configuration by Its conversion to (4S,5R,6S)-(+)-nitropolyzonamine
by: Takagi Yasuyo, et al.
Published: (2000-01-01)

4-[5-(3,5-Difluorophenyl)furan-2-yl]-2,3,7-triazaspiro[4.5]dec-3-en-1-one Hydrochloride
by: Balladka Kunhanna Sarojini, et al.
Published: (2012-08-01)

Novel applications of functionalised orthoesters : towards the synthesis of various natural products
by: Maulide, Nuno
Published: (2007)

Determination of the Qualitative Composition of Biologically Active Substances of Extracts of In Vitro Callus, Cell Suspension, and Root Cultures of the Medicinal Plant <i>Rhaponticum carthamoides</i>
by: Lyudmila Asyakina, et al.
Published: (2021-03-01)

Crystal structure of rac-3,9-bis(2,6-difluorophenyl)-2,4,8,10-tetraoxaspiro[5.5]undecane
by: Liang Chen, et al.
Published: (2015-02-01)

Reverberating Historical Privilege of a “Middling” Sort of Settler Family
by: Avril Bell
Published: (2020-04-01)

The Piancatelli Rearrangement: New Applications for an Intriguing Reaction
by: Francesca Quartieri, et al.
Published: (2013-10-01)

Testing the Toxicity of <i>Stachybotrys chartarum</i> in Indoor Environments—A Case Study
by: Marlena Piontek, et al.
Published: (2021-03-01)

Βιβλιοκρισία του: ΑΝGELIKI E. LAIOU - CECILE MORRISSON, The Byzantine Economy (Cambridge Medieval Textbooks), New York 2007
by: Μαρία ΓΕΡΟΛΥΜΑΤΟΥ
Published: (2011-09-01)

Determination of the Qualitative Composition of Biologically-Active Substances of Extracts of In Vitro Callus, Cell Suspension, and Root Cultures of the Medicinal Plant <i>Rhodiola Rosea</i>
by: Lyudmila Asyakina, et al.
Published: (2021-02-01)

Biologia química: uma estratégia moderna para a pesquisa em produtos naturais Chemical biology: a modern strategy for the natural products research
by: Mônica Tallarico Pupo, et al.
Published: (2007-12-01)

Synthesis and Evaluation of C2-Symmetric SPIROL-Based <i>bis</i>-Oxazoline Ligands
by: Siyuan Sun, et al.
Published: (2021-09-01)