Spirocyclic Motifs in Natural Products

Spirocyclic Motifs in Natural Products

Spirocyclic motifs are emerging privileged structures for drug discovery. They are also omnipresent in the natural products domain. However, until today, no attempt to analyze the structural diversity of various spirocyclic motifs occurring in natural products and their relative populations with uni...

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Bibliographic Details
Main Authors: Evgeny Chupakhin, Olga Babich, Alexander Prosekov, Lyudmila Asyakina, Mikhail Krasavin
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Molecules
Subjects:
natural products
spirocycles
chemical diversity
biological activity
privileged structures
Online Access:https://www.mdpi.com/1420-3049/24/22/4165
Description
Summary:Spirocyclic motifs are emerging privileged structures for drug discovery. They are also omnipresent in the natural products domain. However, until today, no attempt to analyze the structural diversity of various spirocyclic motifs occurring in natural products and their relative populations with unique compounds reported in the literature has been undertaken. This review aims to fill that void and analyze the diversity of structurally unique natural products containing spirocyclic moieties of various sizes.
ISSN:1420-3049

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