Roscovitine suppresses CD4+ T cells and T cell-mediated experimental uveitis.

Roscovitine suppresses CD4+ T cells and T cell-mediated experimental uveitis.

T cells are essential for the development of uveitis and other autoimmune diseases. After initial activation, CD4+ lymphocytes express the co-stimulatory molecule OX40 that plays an important role in T cell proliferation. Cyclin dependent kinase 2 (CdK2) plays a pivotal role in the cell cycle transi...

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Bibliographic Details
Main Authors: Zili Zhang, Qi Liu, Konstantin S Leskov, Xiumei Wu, Jie Duan, Gary L Zhang, Mark Hall, James T Rosenbaum
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3832440?pdf=render

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http://europepmc.org/articles/PMC3832440?pdf=render

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