Retinal region-dependent susceptibility of capillaries to high-concentration oxygen exposure and vascular endothelial growth factor receptor inhibition in neonatal mice

Retinal blood flow insufficiency due to capillary loss induces hypoxia in the retina, leading to an abnormal angiogenesis, relating to ischemic retinopathy. To better understand the mechanism and process of retinal capillary regression, we examined the process of hyperoxia- and vascular endothelial...

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Bibliographic Details
Main Authors: Naoto Iizuka, Tsutomu Nakahara, Hiroko Ushikubo, Asami Mori, Kenji Sakamoto, Kunio Ishii
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Journal of Pharmacological Sciences
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861315001930