Ultra-High-Frequency Reprogramming of Individual Long-Term Hematopoietic Stem Cells Yields Low Somatic Variant Induced Pluripotent Stem Cells

Ultra-High-Frequency Reprogramming of Individual Long-Term Hematopoietic Stem Cells Yields Low Somatic Variant Induced Pluripotent Stem Cells

Summary: Efficiency of reprogramming of human cells into induced pluripotent stem cells (iPSCs) has remained low. We report that individual adult human CD49f+ long-term hematopoietic stem cells (LT-HSCs) can be reprogrammed into iPSCs at close to 50% efficiency using Sendai virus transduction. This...

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Bibliographic Details
Main Authors: Kai Wang, Anthony K. Guzman, Zi Yan, Shouping Zhang, Michael Y. Hu, Mehdi B. Hamaneh, Yi-Kuo Yu, Seda Tolu, Jinghang Zhang, Holly E. Kanavy, Kenny Ye, Boris Bartholdy, Eric E. Bouhassira
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719301834

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http://www.sciencedirect.com/science/article/pii/S2211124719301834

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