Atherogenic Index of Plasma: A Marker for Undetectable Dyslipidaemia among Lichen Planus Patients

• Main Authors: Noha Mohammed Dawoud, Ola Ahmed Bakry, Mohammed Abd el moneim Shoeib, Nora Abd El satar Dawood
• Format: Article
• Language: English
• Published: JCDR Research and Publications Private Limited 2019-01-01
• Series: Journal of Clinical and Diagnostic Research
• Subjects: cholesterol; chronic inflammatory cutaneous; lipoprotein
• Online Access: https://jcdr.net/articles/PDF/12496/39639_CE[Ra1]_F(AC)_PF1(AJ_SHU)_PN(SL).pdf

Introduction: Lichen Planus (LP) is a chronic inflammatory cutaneous disease. Some studies investigated its association with Dyslipidaemia as a main contributing factor for cardiovascular insults. Atherogenic Index of Plasma (AIP) is a strong factor for suspecting that risk. Aim: To investigate lipid profile and calculate AIP in LP patients to early detect atherogenic Dyslipidaemia, if present. Materials and Methods: This case-control study investigated 40 LP patients and 20 age, gender and body mass index (BMI) matched healthy volunteers. Lipid profile of all subjects was evaluated. AIP was estimated as Log {Triglycerides (TGs)/ High Density Lipoprotein-Cholesterol (HDL-C)} and accordingly, patients were categorised into high, medium and low cardiovascular risk patients. Results: Dyslipidaemia was detected in 47.5% of patients, while all control subjects had normal lipid profile (p<0.001). High Total Cholesterol (TC) and Low Density Lipoprotein-Cholesterol (LDL-C) mean values were significantly associated with LP patients as compared to controls (p<0.001 for both), while no significant differences regarding HDL-C and TG levels have been detected. AIP was significantly elevated in LP patients compared to controls (p=0.002). Most of the patients (72.5%) have high cardiovascular risk versus 30% of controls (p=0.004). About one-third of the high cardiovascular risk patients (31.9%) had no dyslipidemia. High risk patients tend to be of older age with no significant differences regarding gender or disease duration. Conclusion: AIP is a good predictor of cardiovascular risk in LP patients even in presence of normal lipid profile and should be evaluated in every case to permit earlier management.