Rapid High-Yield Production of Functional SARS-CoV-2 Receptor Binding Domain by Viral and Non-Viral Transient Expression for Pre-Clinical Evaluation

Rapid High-Yield Production of Functional SARS-CoV-2 Receptor Binding Domain by Viral and Non-Viral Transient Expression for Pre-Clinical Evaluation

Vaccine design strategies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are focused on the Spike protein or its subunits as the main antigen target of neutralizing antibodies. In this work, we propose rapid production methods of an extended segment of the Spike Receptor Bindin...

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Bibliographic Details
Main Authors: Omar Farnós, Alina Venereo-Sánchez, Xingge Xu, Cindy Chan, Shantoshini Dash, Hanan Chaabane, Janelle Sauvageau, Fouad Brahimi, Uri Saragovi, Denis Leclerc, Amine A. Kamen
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Vaccines
Subjects:
SARS-CoV-2 Spike Receptor Binding Domain
HEK293SF suspension cells
vaccine bioprocess
RBD
COVID-19 vaccine
bioreactor
Online Access:https://www.mdpi.com/2076-393X/8/4/654

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