Longitudinal assessment of B-RAF V595E levels in the peripheral cell-free tumor DNA of a 10-year-old spayed female Korean Jindo dog with unresectable metastatic urethral transitional cell carcinoma for monitoring the treatment response to a RAF inhibitor (sorafenib)

Longitudinal assessment of B-RAF V595E levels in the peripheral cell-free tumor DNA of a 10-year-old spayed female Korean Jindo dog with unresectable metastatic urethral transitional cell carcinoma for monitoring the treatment response to a RAF inhibitor (sorafenib)

Transitional cell carcinoma (TCC) is the most common malignant tumor of the canine urinary tract. In this case study, a dog with metastatic urethral TCC was treated with sorafenib. The tumor expression levels of receptor tyrosine kinase genes, including VEGFR-1, VEGFR-2, PDGFR-α, PDGFR-β, ALK, EGFR,...

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Bibliographic Details
Main Authors: Jung-Hyun Kim, Dana Hyunjung Ahn, Je-Sung Moon, Hyun-Jung Han, Kieun Bae, Kyong-Ah Yoon
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Veterinary Quarterly
Subjects:
dog
transitional cell carcinoma
circulating cell-free tumor dna
b-raf v595e
vascular endothelial growth factor
sorafenib
Online Access:http://dx.doi.org/10.1080/01652176.2021.1905194

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