Of men not mice: Bactericidal/permeability-increasing protein (BPI) expressed in human macrophages acts as a phagocytic receptor and modulates entry and replication of Gram-negative bacteria.

Of men not mice: Bactericidal/permeability-increasing protein (BPI) expressed in human macrophages acts as a phagocytic receptor and modulates entry and replication of Gram-negative bacteria.

Macrophages as immune cells prevent the spreading of pathogens by means of active phagocytosis and killing. We report here the presence of an anti-microbial protein, bactericidal/permeability-increasing protein (BPI) in human macrophages, which actively participates in engulfment and killing of Gram...

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Bibliographic Details
Main Authors: Arjun Balakrishnan, Markus Schnare, Dipshikha Chakravortty
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Immunology
Subjects:
Gram-Negative Bacteria
innate immunity
phagocytic receptor
Macrophage evolution
Bacterial niche
Anti-microbial protein.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00455/full

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