FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer

FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer

Abstract RNASET2 (Ribonuclease T2) functions as a tumor suppressor in preventing ovarian tumorigenesis. However, the mechanisms underlying the regulation of RNASET2 protein are completely unknown. Here we identified the F-box protein FBXO6, a substrate recognition subunit of an SCF (Skp1-Cul1-F-box...

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Bibliographic Details
Main Authors: Mei Ji, Zhao Zhao, Yue Li, Penglin Xu, Jia Shi, Zhe Li, Kaige Wang, Xiaotian Huang, Bin Liu
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03580-4

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