Multipotent progenitors and hematopoietic stem cells arise independently from hemogenic endothelium in the mouse embryo

Multipotent progenitors and hematopoietic stem cells arise independently from hemogenic endothelium in the mouse embryo

Summary: During embryogenesis, waves of hematopoietic progenitors develop from hemogenic endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSCs). Although previous studies have shown that yolk-sac-derived erythromyeloid progenitors and HSCs emerge from distinct popul...

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Bibliographic Details
Main Authors: Tessa Dignum, Barbara Varnum-Finney, Sanjay R. Srivatsan, Stacey Dozono, Olivia Waltner, Adam M. Heck, Takashi Ishida, Cynthia Nourigat-McKay, Dana L. Jackson, Shahin Rafii, Cole Trapnell, Irwin D. Bernstein, Brandon Hadland
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Cell Reports
Subjects:
hematopoietic stem cell
HSC
multipotent progenitor
MPP
aorta-gonad-mesonephros
AGM
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721011190

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