Disulfiram/Copper Induces Antitumor Activity against Both Nasopharyngeal Cancer Cells and Cancer-Associated Fibroblasts through ROS/MAPK and Ferroptosis Pathways

Disulfiram/Copper Induces Antitumor Activity against Both Nasopharyngeal Cancer Cells and Cancer-Associated Fibroblasts through ROS/MAPK and Ferroptosis Pathways

Disulfiram/copper (DSF/Cu) is a promising antitumor reagent for clinical application due to its excellent anticancer activity and safety. However, the anticancer mechanism of DSF/Cu has not been fully elucidated. Our study showed that DSF/Cu strongly induced cytotoxic effects on both nasopharyngeal...

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Bibliographic Details
Main Authors: Yiqiu Li, Fangfang Chen, Jun Chen, Siocheong Chan, Yi He, Wanli Liu, Ge Zhang
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
nasopharyngeal cancer (npc)
(disulfiram/copper) dsf/cu
apoptosis
ferroptosis
cancer-associated fibroblasts (cafs)
Online Access:https://www.mdpi.com/2072-6694/12/1/138

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