Absorption and degradation of sulfated polysaccharide from pacific abalone in in vitro and in vivo models

Absorption and degradation of sulfated polysaccharide from pacific abalone in in vitro and in vivo models

Various bioactivities of sulfated polysaccharides have been demonstrated, but the exact mechanisms involved are still unclear, which can be mainly attributed to a lack of recognition of polysaccharides metabolism in vivo. To define action mechanisms of sulfated polysaccharide from pacific abalone (A...

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Main Authors: Chunqing Ai, Na Ma, Xiaona Sun, Mengmeng Duan, Sufeng Wu, Jingfeng Yang, Chengrong Wen, Shuang Song
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Journal of Functional Foods
Subjects:
Sulfated polysaccharide
Fermentation
Gut microbiota
Digestion
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464617302608
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spelling doaj-aea637474d324f6ebf9637cd97daffbe2021-04-30T07:10:30ZengElsevierJournal of Functional Foods1756-46462017-08-0135127133Absorption and degradation of sulfated polysaccharide from pacific abalone in in vitro and in vivo modelsChunqing Ai0Na Ma1Xiaona Sun2Mengmeng Duan3Sufeng Wu4Jingfeng Yang5Chengrong Wen6Shuang Song7School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China; National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, PR China; National & Local Joint Engineering Laboratory for Marine Bioactive Polysaccharide Development and Application, Dalian Polytechnic University, Dalian 116034, PR ChinaSchool of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR ChinaSchool of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR ChinaSchool of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR ChinaSchool of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR ChinaSchool of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR ChinaSchool of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR ChinaSchool of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China; National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, PR China; National & Local Joint Engineering Laboratory for Marine Bioactive Polysaccharide Development and Application, Dalian Polytechnic University, Dalian 116034, PR China; Corresponding author at: School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China.Various bioactivities of sulfated polysaccharides have been demonstrated, but the exact mechanisms involved are still unclear, which can be mainly attributed to a lack of recognition of polysaccharides metabolism in vivo. To define action mechanisms of sulfated polysaccharide from pacific abalone (AGSP), its metabolic characteristics were first evaluated in a mice model. The result showed that AGSP was hard to be absorbed into plasma, and most might be excreted from the body via feces. The in vitro models showed that human digestive juices had no effects on AGSP, and AGSP could exert its bioactivities by modulating the gut microbiota composition. It was noteworthy that small AGSP fragment was also hard to be absorbed by the body. In summary, this study demonstrated that various bioactivities of AGSP could be mainly attributed to the modulation of the gut microbiota rather than direct action on body organs far away from the digestive tract.http://www.sciencedirect.com/science/article/pii/S1756464617302608Sulfated polysaccharideFermentationGut microbiotaDigestion
collection DOAJ
language English
format Article
sources DOAJ
author Chunqing Ai
Na Ma
Xiaona Sun
Mengmeng Duan
Sufeng Wu
Jingfeng Yang
Chengrong Wen
Shuang Song
spellingShingle Chunqing Ai
Na Ma
Xiaona Sun
Mengmeng Duan
Sufeng Wu
Jingfeng Yang
Chengrong Wen
Shuang Song
Absorption and degradation of sulfated polysaccharide from pacific abalone in in vitro and in vivo models
Journal of Functional Foods
Sulfated polysaccharide
Fermentation
Gut microbiota
Digestion
author_facet Chunqing Ai
Na Ma
Xiaona Sun
Mengmeng Duan
Sufeng Wu
Jingfeng Yang
Chengrong Wen
Shuang Song
author_sort Chunqing Ai
title Absorption and degradation of sulfated polysaccharide from pacific abalone in in vitro and in vivo models
title_short Absorption and degradation of sulfated polysaccharide from pacific abalone in in vitro and in vivo models
title_full Absorption and degradation of sulfated polysaccharide from pacific abalone in in vitro and in vivo models
title_fullStr Absorption and degradation of sulfated polysaccharide from pacific abalone in in vitro and in vivo models
title_full_unstemmed Absorption and degradation of sulfated polysaccharide from pacific abalone in in vitro and in vivo models
title_sort absorption and degradation of sulfated polysaccharide from pacific abalone in in vitro and in vivo models
publisher Elsevier
series Journal of Functional Foods
issn 1756-4646
publishDate 2017-08-01
description Various bioactivities of sulfated polysaccharides have been demonstrated, but the exact mechanisms involved are still unclear, which can be mainly attributed to a lack of recognition of polysaccharides metabolism in vivo. To define action mechanisms of sulfated polysaccharide from pacific abalone (AGSP), its metabolic characteristics were first evaluated in a mice model. The result showed that AGSP was hard to be absorbed into plasma, and most might be excreted from the body via feces. The in vitro models showed that human digestive juices had no effects on AGSP, and AGSP could exert its bioactivities by modulating the gut microbiota composition. It was noteworthy that small AGSP fragment was also hard to be absorbed by the body. In summary, this study demonstrated that various bioactivities of AGSP could be mainly attributed to the modulation of the gut microbiota rather than direct action on body organs far away from the digestive tract.
topic Sulfated polysaccharide
Fermentation
Gut microbiota
Digestion
url http://www.sciencedirect.com/science/article/pii/S1756464617302608
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AT nama absorptionanddegradationofsulfatedpolysaccharidefrompacificabaloneininvitroandinvivomodels
AT xiaonasun absorptionanddegradationofsulfatedpolysaccharidefrompacificabaloneininvitroandinvivomodels
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AT sufengwu absorptionanddegradationofsulfatedpolysaccharidefrompacificabaloneininvitroandinvivomodels
AT jingfengyang absorptionanddegradationofsulfatedpolysaccharidefrompacificabaloneininvitroandinvivomodels
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AT shuangsong absorptionanddegradationofsulfatedpolysaccharidefrompacificabaloneininvitroandinvivomodels
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