Solubility and Thermal Degradation of Quercetin in CO<sub>2</sub>-Expanded Liquids

The solubility of quercetin and its thermal degradation was studied in CO<sub>2</sub>-expanded ethanol and ethyl lactate. An equipment setup was constructed that enabled the separation of the products of degradation while quantifying the solubility of quercetin. Three different condition...

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Main Authors:	Larissa P. Cunico, Andrés Medina Cobo, Said Al-Hamimi, Charlotta Turner
Format:	Article
Language:	English
Published:	MDPI AG 2020-11-01
Series:	Molecules
Subjects:	gas-expanded liquid green solvent quercetin solubility subcritical fluid thermal degradation
Online Access:	https://www.mdpi.com/1420-3049/25/23/5582

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spelling	doaj-aea1e638e71d46c9ac8ada211cf78e0d2020-11-28T00:06:47ZengMDPI AGMolecules1420-30492020-11-01255582558210.3390/molecules25235582Solubility and Thermal Degradation of Quercetin in CO<sub>2</sub>-Expanded LiquidsLarissa P. Cunico0Andrés Medina Cobo1Said Al-Hamimi2Charlotta Turner3Centre for Analysis and Synthesis (CAS), Department of Chemistry, Lund University, P.O. Box 124, SE-221 00 Lund, SwedenCentre for Analysis and Synthesis (CAS), Department of Chemistry, Lund University, P.O. Box 124, SE-221 00 Lund, SwedenCentre for Analysis and Synthesis (CAS), Department of Chemistry, Lund University, P.O. Box 124, SE-221 00 Lund, SwedenCentre for Analysis and Synthesis (CAS), Department of Chemistry, Lund University, P.O. Box 124, SE-221 00 Lund, SwedenThe solubility of quercetin and its thermal degradation was studied in CO<sub>2</sub>-expanded ethanol and ethyl lactate. An equipment setup was constructed that enabled the separation of the products of degradation while quantifying the solubility of quercetin. Three different conditions of temperature were analyzed (308, 323, and 343 K) at 10 MPa. Higher solubility and thermal degradation of quercetin were observed for CO<sub>2</sub>-expanded ethyl lactate in comparison with CO<sub>2</sub>-expanded ethanol. At the same time, as the amount of CO<sub>2</sub> was increased in the CO<sub>2</sub>-expanded liquids mixtures, the thermal degradation of quercetin decreased for almost all the conditions of temperature considered in this work. The importance of considering thermal degradation while performing solubility measurements of compounds that are thermally unstable such as quercetin was highlighted.https://www.mdpi.com/1420-3049/25/23/5582gas-expanded liquidgreen solventquercetinsolubilitysubcritical fluidthermal degradation
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Larissa P. Cunico Andrés Medina Cobo Said Al-Hamimi Charlotta Turner
spellingShingle	Larissa P. Cunico Andrés Medina Cobo Said Al-Hamimi Charlotta Turner Solubility and Thermal Degradation of Quercetin in CO<sub>2</sub>-Expanded Liquids Molecules gas-expanded liquid green solvent quercetin solubility subcritical fluid thermal degradation
author_facet	Larissa P. Cunico Andrés Medina Cobo Said Al-Hamimi Charlotta Turner
author_sort	Larissa P. Cunico
title	Solubility and Thermal Degradation of Quercetin in CO<sub>2</sub>-Expanded Liquids
title_short	Solubility and Thermal Degradation of Quercetin in CO<sub>2</sub>-Expanded Liquids
title_full	Solubility and Thermal Degradation of Quercetin in CO<sub>2</sub>-Expanded Liquids
title_fullStr	Solubility and Thermal Degradation of Quercetin in CO<sub>2</sub>-Expanded Liquids
title_full_unstemmed	Solubility and Thermal Degradation of Quercetin in CO<sub>2</sub>-Expanded Liquids
title_sort	solubility and thermal degradation of quercetin in co<sub>2</sub>-expanded liquids
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2020-11-01
description	The solubility of quercetin and its thermal degradation was studied in CO<sub>2</sub>-expanded ethanol and ethyl lactate. An equipment setup was constructed that enabled the separation of the products of degradation while quantifying the solubility of quercetin. Three different conditions of temperature were analyzed (308, 323, and 343 K) at 10 MPa. Higher solubility and thermal degradation of quercetin were observed for CO<sub>2</sub>-expanded ethyl lactate in comparison with CO<sub>2</sub>-expanded ethanol. At the same time, as the amount of CO<sub>2</sub> was increased in the CO<sub>2</sub>-expanded liquids mixtures, the thermal degradation of quercetin decreased for almost all the conditions of temperature considered in this work. The importance of considering thermal degradation while performing solubility measurements of compounds that are thermally unstable such as quercetin was highlighted.
topic	gas-expanded liquid green solvent quercetin solubility subcritical fluid thermal degradation
url	https://www.mdpi.com/1420-3049/25/23/5582
work_keys_str_mv	AT larissapcunico solubilityandthermaldegradationofquercetinincosub2subexpandedliquids AT andresmedinacobo solubilityandthermaldegradationofquercetinincosub2subexpandedliquids AT saidalhamimi solubilityandthermaldegradationofquercetinincosub2subexpandedliquids AT charlottaturner solubilityandthermaldegradationofquercetinincosub2subexpandedliquids
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Solubility and Thermal Degradation of Quercetin in CO<sub>2</sub>-Expanded Liquids

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