Inhibition of TGFβ-activated kinase 1 promotes inflammation-resolving microglial/macrophage responses and recovery after stroke in ovariectomized female mice

Inhibition of TGFβ-activated kinase 1 promotes inflammation-resolving microglial/macrophage responses and recovery after stroke in ovariectomized female mice

TGFβ-activated kinase 1 (TAK1) is a master regulator that drives multiple cell death and proinflammatory signaling pathways, making it a promising therapeutic target to treat ischemic stroke. However, whether targeting TAK1 could improve stroke outcomes has never been tested in female subjects, hind...

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Bibliographic Details
Main Authors: Yaan Liu, Sicheng Li, Rongrong Wang, Hongjian Pu, Yongfang Zhao, Qing Ye, Yejie Shi
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Neurobiology of Disease
Subjects:
5Z-7-Oxozeaenol
Inflammation
MAP3K7
Ovariectomized mice
TAK1
Transient focal cerebral ischemia
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121000061

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http://www.sciencedirect.com/science/article/pii/S0969996121000061

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