Selective Upregulation of Transcripts for Six Molecules Related to T Cell Costimulation and Phagocyte Recruitment and Activation among 734 Immunity-Related Genes in the Brain during Perforin-Dependent, CD8+ T Cell-Mediated Elimination of Toxoplasma gondii Cysts

Selective Upregulation of Transcripts for Six Molecules Related to T Cell Costimulation and Phagocyte Recruitment and Activation among 734 Immunity-Related Genes in the Brain during Perforin-Dependent, CD8+ T Cell-Mediated Elimination of Toxoplasma gondii Cysts

T. gondii establishes a chronic infection by forming tissue cysts, which can grow into sizes greater than 50 μm in diameter as a consequence of containing hundreds to thousands of organisms surrounded by the cyst wall within infected cells. Our recent studies using murine models uncovered that CD8+...

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Bibliographic Details
Main Authors: Jenny Lutshumba, Eri Ochiai, Qila Sa, Namrata Anand, Yasuhiro Suzuki
Format: Article
Language:English
Published: American Society for Microbiology 2020-04-01
Series:mSystems
Subjects:
cd8+ cytotoxic t cells
perforin
t cell invasion
coactivation molecules
phagocytes
chemokine receptor
costimulatory molecules
large-scale gene expression profile
Online Access:https://doi.org/10.1128/mSystems.00189-20

Internet

https://doi.org/10.1128/mSystems.00189-20

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