Development of Agonist-Based PROTACs Targeting Liver X Receptor

Development of Agonist-Based PROTACs Targeting Liver X Receptor

Liver X receptors (LXRs) belong to the nuclear hormone receptor superfamily and function as ligand-dependent transcription factors that regulate cholesterol homeostasis, lipid homeostasis, and immune responses. LXR antagonists are promising treatments for hypercholesterolemia and diabetes. However,...

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Bibliographic Details
Main Authors: Hanqiao Xu, Nobumichi Ohoka, Hidetomo Yokoo, Kanako Nemoto, Takashi Ohtsuki, Hiroshi Matsufuji, Mikihiko Naito, Takao Inoue, Genichiro Tsuji, Yosuke Demizu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Chemistry
Subjects:
liver X receptor
PROTAC
ubiquitin-proteasome system
von Hippel-Lindau
protein degradation
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.674967/full

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