Exercise Training Attenuates Hypertension Through TLR4/MyD88/NF-κB Signaling in the Hypothalamic Paraventricular Nucleus

Exercise Training Attenuates Hypertension Through TLR4/MyD88/NF-κB Signaling in the Hypothalamic Paraventricular Nucleus

Exercise training (ExT) is beneficial for cardiovascular health, yet the central mechanism by which aerobic ExT attenuates the hypertensive responses remains unclear. Activation of pro-inflammatory cytokines (PICs) in the hypothalamic paraventricular nucleus (PVN) is important for the sympathoexcita...

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Bibliographic Details
Main Authors: Jie Qi, Xiao-Jing Yu, Li-Yan Fu, Kai-Li Liu, Tian-Tian Gao, Jia-Wei Tu, Kai B. Kang, Xiao-Lian Shi, Hong-Bao Li, Ying Li, Yu-Ming Kang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Neuroscience
Subjects:
hypothalamic paraventricular nucleus
exercise training
hypertension
pro-inflammatory cytokines
TLR4
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.01138/full

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