IgG and IgA autoantibodies against L1 ORF1p expressed in granulocytes correlate with granulocyte consumption and disease activity in pediatric systemic lupus erythematosus

IgG and IgA autoantibodies against L1 ORF1p expressed in granulocytes correlate with granulocyte consumption and disease activity in pediatric systemic lupus erythematosus

Abstract Background Most patients with systemic lupus erythematosus (SLE) have IgG autoantibodies against the RNA-binding p40 (ORF1p) protein encoded by the L1 retroelement. This study tested if these autoantibodies are also present in children with pediatric SLE (pSLE) and if the p40 protein itself...

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Bibliographic Details
Main Authors: Kennedy C. Ukadike, Kathryn Ni, Xiaoxing Wang, Martin S. Taylor, John LaCava, Lauren M. Pachman, Mary Eckert, Anne Stevens, Christian Lood, Tomas Mustelin
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Arthritis Research & Therapy
Subjects:
Pediatric lupus erythematosus
Long interspersed nuclear element
Retrotransposon
Autoantibodies
Neutrophils
Online Access:https://doi.org/10.1186/s13075-021-02538-3

Internet

https://doi.org/10.1186/s13075-021-02538-3

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