The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level

The integrity of the stratified epithelia relies on controlled cell turnover but it is unclear how mRNA binding proteins regulates this. Here, the authors show that the RNA binding protein Y-box binding protein-1 translationally represses cytokines, so preventing senescence and maintaining epidermal...

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Main Authors:	Eunjeong Kwon, Kristina Todorova, Jun Wang, Rastislav Horos, Kevin K. Lee, Victor A. Neel, Gian Luca Negri, Poul H. Sorensen, Sam W. Lee, Matthias W. Hentze, Anna Mandinova
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-04092-0

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spelling	doaj-ae77c37590464e83bc58037121dc3a322021-05-11T09:37:22ZengNature Publishing GroupNature Communications2041-17232018-04-019111610.1038/s41467-018-04092-0The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional levelEunjeong Kwon0Kristina Todorova1Jun Wang2Rastislav Horos3Kevin K. Lee4Victor A. Neel5Gian Luca Negri6Poul H. Sorensen7Sam W. Lee8Matthias W. Hentze9Anna Mandinova10Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical SchoolCutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical SchoolCutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical SchoolEuropean Molecular Biology Laboratory (EMBL)Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical SchoolDepartment of Dermatology, Massachusetts General Hospital and Harvard Medical SchoolDepartment of Pathology and Laboratory Medicine, University of British ColumbiaDepartment of Pathology and Laboratory Medicine, University of British ColumbiaCutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical SchoolEuropean Molecular Biology Laboratory (EMBL)Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical SchoolThe integrity of the stratified epithelia relies on controlled cell turnover but it is unclear how mRNA binding proteins regulates this. Here, the authors show that the RNA binding protein Y-box binding protein-1 translationally represses cytokines, so preventing senescence and maintaining epidermal homeostasis.https://doi.org/10.1038/s41467-018-04092-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Eunjeong Kwon Kristina Todorova Jun Wang Rastislav Horos Kevin K. Lee Victor A. Neel Gian Luca Negri Poul H. Sorensen Sam W. Lee Matthias W. Hentze Anna Mandinova
spellingShingle	Eunjeong Kwon Kristina Todorova Jun Wang Rastislav Horos Kevin K. Lee Victor A. Neel Gian Luca Negri Poul H. Sorensen Sam W. Lee Matthias W. Hentze Anna Mandinova The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level Nature Communications
author_facet	Eunjeong Kwon Kristina Todorova Jun Wang Rastislav Horos Kevin K. Lee Victor A. Neel Gian Luca Negri Poul H. Sorensen Sam W. Lee Matthias W. Hentze Anna Mandinova
author_sort	Eunjeong Kwon
title	The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level
title_short	The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level
title_full	The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level
title_fullStr	The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level
title_full_unstemmed	The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level
title_sort	rna-binding protein ybx1 regulates epidermal progenitors at a posttranscriptional level
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-04-01
description	The integrity of the stratified epithelia relies on controlled cell turnover but it is unclear how mRNA binding proteins regulates this. Here, the authors show that the RNA binding protein Y-box binding protein-1 translationally represses cytokines, so preventing senescence and maintaining epidermal homeostasis.
url	https://doi.org/10.1038/s41467-018-04092-0
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The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level

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