Antagonistic interaction between Nodal and insulin modulates pancreatic β-cell proliferation and survival

Antagonistic interaction between Nodal and insulin modulates pancreatic β-cell proliferation and survival

Abstract Background Insulin signaling pathway in β-cell is essential to promote β-cells proliferation and survival, while Nodal–ALK7–Smad3 signaling involves β-cells apoptosis. We attempted to address inter-relationship between Nodal and insulin in modulating β-cell proliferation and apoptosis. Meth...

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Bibliographic Details
Main Authors: Junfeng Li, Zhihong Wang, Liwei Ren, Linling Fan, Wenjuan Liu, Yaojing Jiang, Harry K. Lau, Rui Liu, Qinghua Wang
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Cell Communication and Signaling
Subjects:
Nodal
Insulin
Diabetes
β-Cell
Autocrine
Online Access:http://link.springer.com/article/10.1186/s12964-018-0288-0

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http://link.springer.com/article/10.1186/s12964-018-0288-0

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