A novel monoclonal antibody against the von Willebrand Factor A2 domain reduces its cleavage by ADAMTS13

A novel monoclonal antibody against the von Willebrand Factor A2 domain reduces its cleavage by ADAMTS13

Abstract We developed a novel murine monoclonal antibody (mAb) against the C-terminal α-helix of the human von Willebrand factor A2, designated SZ-179. We showed that SZ-179 inhibited the interactions between VWF and ADAMTS13 and prevented the degradation of high molecular weight VWF multimers. Impo...

Full description

Bibliographic Details
Main Authors: Lulu Zhang, Jian Su, Fei Shen, Zhenni Ma, Yiming Zhao, Lijun Xia, Changgeng Ruan
Format: Article
Language:English
Published: BMC 2017-02-01
Series:Journal of Hematology & Oncology
Subjects:
von Willebrand factor
Monoclonal antibody
ADAMTS13
Online Access:http://link.springer.com/article/10.1186/s13045-017-0407-1

Internet

http://link.springer.com/article/10.1186/s13045-017-0407-1

Similar Items