Low-dose corticosteroid and gallium-67 scintigraphy and acute interstitial nephritis

We describe a 19-year-old male who developed diclofenac-induced acute inters-titial nephritis (AIN). Diffuse mononuclear cell infiltration was confirmed by renal biopsy and a Gallium (Ga)-67 scintigraphy revealed diffuse uptake of the isotope in both kidneys. His renal function had gradually and pro...

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Bibliographic Details
Main Authors: Tetsu Akimoto, Ryoko Horikoshi, Shigeaki Muto, Eiji Kusano
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2014-01-01
Series:Saudi Journal of Kidney Diseases and Transplantation
Online Access:http://www.sjkdt.org/article.asp?issn=1319-2442;year=2014;volume=25;issue=4;spage=864;epage=868;aulast=Akimoto
Description
Summary:We describe a 19-year-old male who developed diclofenac-induced acute inters-titial nephritis (AIN). Diffuse mononuclear cell infiltration was confirmed by renal biopsy and a Gallium (Ga)-67 scintigraphy revealed diffuse uptake of the isotope in both kidneys. His renal function had gradually and promptly recovered after initiation of low-dose prednisolone (0.5 mg/kg/day). There are no established criteria for the administration of corticosteroids in the treatment of drug-induced AIN. Moreover, no clear recommendations regarding the optimal dose and duration of steroid administration in the treatment for drug-induced AIN has been established. In addition, we discuss the clinical benefit of steroid treatment and the diagnostic impact of Ga scanning on the management of drug-induced AIN.
ISSN:1319-2442