Three-dimensional growth as multicellular spheroid activates the proangiogenic phenotype of colorectal carcinoma cells via LFA-1-dependent VEGF: implications on hepatic micrometastasis

Three-dimensional growth as multicellular spheroid activates the proangiogenic phenotype of colorectal carcinoma cells via LFA-1-dependent VEGF: implications on hepatic micrometastasis

<p>Abstract</p> <p>Background</p> <p>The recruitment of vascular stromal and endothelial cells is an early event occurring during cancer cell growth at premetastatic niches, but how the microenvironment created by the initial three-dimensional (3D) growth of cancer cell...

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Bibliographic Details
Main Authors: Muruzabal Francisco J, Mendoza Lorea, Martínez Iñigo, Lopategi Aritz, Jaureguibeitia Arrate, Arteta Beatriz, Valcárcel María, Salado Clarisa, Vidal-Vanaclocha Fernando
Format: Article
Language:English
Published: BMC 2008-10-01
Series:Journal of Translational Medicine
Online Access:http://www.translational-medicine.com/content/6/1/57

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