Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are structurally and functionally distinct proteins containing specific domains and motifs that enable the proteins to bind certain nucleotide sequences, particularly those found in human telomeres. In human malignant cells (HMCs), hnRNP-A1&#8212...

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Main Authors:	Sergey S. Shishkin, Leonid I. Kovalev, Natalya V. Pashintseva, Marina A. Kovaleva, Ksenia Lisitskaya
Format:	Article
Language:	English
Published:	MDPI AG 2019-02-01
Series:	International Journal of Molecular Sciences
Subjects:	heterogeneous nuclear ribonucleoproteins telomere telomerase human malignant cells
Online Access:	https://www.mdpi.com/1422-0067/20/3/745

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spelling	doaj-ae5fe44218d149d8a58b4db03f3380682020-11-24T21:40:42ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-02-0120374510.3390/ijms20030745ijms20030745Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant CellsSergey S. Shishkin0Leonid I. Kovalev1Natalya V. Pashintseva2Marina A. Kovaleva3Ksenia Lisitskaya4Laboratory of Biomedical Research, Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Leninsky Prospekt, 33, bld. 2, 119071 Moscow, RussiaLaboratory of Biomedical Research, Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Leninsky Prospekt, 33, bld. 2, 119071 Moscow, RussiaLaboratory of Biomedical Research, Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Leninsky Prospekt, 33, bld. 2, 119071 Moscow, RussiaLaboratory of Biomedical Research, Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Leninsky Prospekt, 33, bld. 2, 119071 Moscow, RussiaLaboratory of Biomedical Research, Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Leninsky Prospekt, 33, bld. 2, 119071 Moscow, RussiaHeterogeneous nuclear ribonucleoproteins (hnRNPs) are structurally and functionally distinct proteins containing specific domains and motifs that enable the proteins to bind certain nucleotide sequences, particularly those found in human telomeres. In human malignant cells (HMCs), hnRNP-A1—the most studied hnRNP—is an abundant multifunctional protein that interacts with telomeric DNA and affects telomerase function. In addition, it is believed that other hnRNPs in HMCs may also be involved in the maintenance of telomere length. Accordingly, these proteins are considered possible participants in the processes associated with HMC immortalization. In our review, we discuss the results of studies on different hnRNPs that may be crucial to solving molecular oncological problems and relevant to further investigations of these proteins in HMCs.https://www.mdpi.com/1422-0067/20/3/745heterogeneous nuclear ribonucleoproteinstelomeretelomerasehuman malignant cells
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sergey S. Shishkin Leonid I. Kovalev Natalya V. Pashintseva Marina A. Kovaleva Ksenia Lisitskaya
spellingShingle	Sergey S. Shishkin Leonid I. Kovalev Natalya V. Pashintseva Marina A. Kovaleva Ksenia Lisitskaya Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells International Journal of Molecular Sciences heterogeneous nuclear ribonucleoproteins telomere telomerase human malignant cells
author_facet	Sergey S. Shishkin Leonid I. Kovalev Natalya V. Pashintseva Marina A. Kovaleva Ksenia Lisitskaya
author_sort	Sergey S. Shishkin
title	Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells
title_short	Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells
title_full	Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells
title_fullStr	Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells
title_full_unstemmed	Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells
title_sort	heterogeneous nuclear ribonucleoproteins involved in the functioning of telomeres in malignant cells
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2019-02-01
description	Heterogeneous nuclear ribonucleoproteins (hnRNPs) are structurally and functionally distinct proteins containing specific domains and motifs that enable the proteins to bind certain nucleotide sequences, particularly those found in human telomeres. In human malignant cells (HMCs), hnRNP-A1—the most studied hnRNP—is an abundant multifunctional protein that interacts with telomeric DNA and affects telomerase function. In addition, it is believed that other hnRNPs in HMCs may also be involved in the maintenance of telomere length. Accordingly, these proteins are considered possible participants in the processes associated with HMC immortalization. In our review, we discuss the results of studies on different hnRNPs that may be crucial to solving molecular oncological problems and relevant to further investigations of these proteins in HMCs.
topic	heterogeneous nuclear ribonucleoproteins telomere telomerase human malignant cells
url	https://www.mdpi.com/1422-0067/20/3/745
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Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells

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