STIM Proteins and Orai Ca2+ Channels Are Involved in the Intracellular Pathways Activated by TLQP-21 in RAW264.7 Macrophages

STIM Proteins and Orai Ca2+ Channels Are Involved in the Intracellular Pathways Activated by TLQP-21 in RAW264.7 Macrophages

TLQP-21 is a neuropeptide which has been implicated in regulation of nociception and other relevant physiologic functions. Although recent studies identified C3a and gC1q receptors as targets for TLQP-21, its intracellular molecular mechanisms of action remain largely unidentified. Our aim was (i) t...

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Bibliographic Details
Main Authors: Laura Molteni, Laura Rizzi, Elena Bresciani, Ramona Meanti, Jean-Alain Fehrentz, Pascal Verdié, Robert J. Omeljaniuk, Giuseppe Biagini, Vittorio Locatelli, Antonio Torsello
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
TLQP-21
SOCE
STIM-1
macrophages
calcium
receptor
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01386/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01386/full

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