Eco-Friendly Multi-Component Synthesis of γ-Spiroiminolactones in Water

• Main Authors: Hamid Reza Safaei, Mohsen Shekouhy
• Format: Article
• Language: English
• Published: Slovenian Chemical Society 2017-12-01
• Series: Acta Chimica Slovenica
• Subjects: γ-spiroiminolactone; water; multi-component reaction; isocyanide; surfactant
• Online Access: https://journals.matheo.si/index.php/ACSi/article/view/3773

γ-Spiroiminolactone derivatives can be  synthesized by means of a one-pot three-component reaction between cyclic carbonyl compounds (isatin, acenaphthoquinone, ninhydrin), activated α-methylene groups and isocyanides in water using sodium dodecyl sulfate (SDS) as a commercial available and very cheap surfactant compound. All products were obtained in good to excellent yields without formation of any by-products in water as a green and benign reaction medium. Moreover, presented method was successfully applied for the synthesis of some novel bis(spiroiminolactone) derivatives.