Optimization of two opposing neutron beams parameters in dynamical (B/Gd) neutron cancer therapy
We demonstrate how the therapeutic utility index and the ballistic index for dynamical neutron cancer therapy (NCT) with two opposing neutron beams form a nonlinear optimization problem. In this problem, the modulation frequencies ω and ϖ of the beams and the relative time advance...
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| Format: | Article |
| Language: | English |
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National Research Nuclear University (MEPhI)
2019-03-01
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| Series: | Nuclear Energy and Technology |
| Online Access: | https://nucet.pensoft.net/article/32239/download/pdf/ |
| Summary: | We demonstrate how the therapeutic utility index and the ballistic index for dynamical neutron cancer therapy (NCT) with two opposing neutron beams form a nonlinear optimization problem. In this problem, the modulation frequencies ω and ϖ of the beams and the relative time advance ε are the control variables. A Pareto optimal control vector ω* = (ω*, ϖ*, ε*) for this problem is identified and reported for the first time. The utility index is shown to be remarkably periodically discontinuous in ε, even in the neighborhood of ε*.
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| ISSN: | 2452-3038 |