Insight into Inhibitor Binding in the Eukaryotic Proteasome: Computations of the 20S CP

Insight into Inhibitor Binding in the Eukaryotic Proteasome: Computations of the 20S CP

A combination of molecular dynamics (MD) simulations and computational analyses uncovers structural features that may influence substrate passage and exposure to the active sites within the proteolytic chamber of the 20S proteasome core particle (CP). MD simulations of the CP reveal relaxation dynam...

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Bibliographic Details
Main Authors: Milan Hodošček, Nadia Elghobashi-Meinhardt
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:International Journal of Molecular Sciences
Subjects:
proteasome
core particle (CP)
SyringolinA inhibitor
proteolytic
active site
molecular dynamics (MD)
simulations
electrostatic interactions
Online Access:https://www.mdpi.com/1422-0067/19/12/3858

Internet

https://www.mdpi.com/1422-0067/19/12/3858

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