Spatiotemporal control of coacervate formation within liposomes

The understanding of liquid-liquid phase separation is crucial to cell biology and benefits from cell-mimicking in vitro assays. Here, the authors develop a microfluidic platform to study coacervate formation inside liposomes and show the potential of these hybrid systems to create synthetic cells.

Bibliographic Details
Main Authors:	Siddharth Deshpande, Frank Brandenburg, Anson Lau, Mart G. F. Last, Willem Kasper Spoelstra, Louis Reese, Sreekar Wunnava, Marileen Dogterom, Cees Dekker
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-09855-x

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spelling	doaj-ae4c34d7c7784f8eba43706f516aa4e92021-05-11T11:30:00ZengNature Publishing GroupNature Communications2041-17232019-04-0110111110.1038/s41467-019-09855-xSpatiotemporal control of coacervate formation within liposomesSiddharth Deshpande0Frank Brandenburg1Anson Lau2Mart G. F. Last3Willem Kasper Spoelstra4Louis Reese5Sreekar Wunnava6Marileen Dogterom7Cees Dekker8Department of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of TechnologyDepartment of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of TechnologyDepartment of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of TechnologyDepartment of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of TechnologyDepartment of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of TechnologyDepartment of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of TechnologyDepartment of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of TechnologyDepartment of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of TechnologyDepartment of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of TechnologyThe understanding of liquid-liquid phase separation is crucial to cell biology and benefits from cell-mimicking in vitro assays. Here, the authors develop a microfluidic platform to study coacervate formation inside liposomes and show the potential of these hybrid systems to create synthetic cells.https://doi.org/10.1038/s41467-019-09855-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Siddharth Deshpande Frank Brandenburg Anson Lau Mart G. F. Last Willem Kasper Spoelstra Louis Reese Sreekar Wunnava Marileen Dogterom Cees Dekker
spellingShingle	Siddharth Deshpande Frank Brandenburg Anson Lau Mart G. F. Last Willem Kasper Spoelstra Louis Reese Sreekar Wunnava Marileen Dogterom Cees Dekker Spatiotemporal control of coacervate formation within liposomes Nature Communications
author_facet	Siddharth Deshpande Frank Brandenburg Anson Lau Mart G. F. Last Willem Kasper Spoelstra Louis Reese Sreekar Wunnava Marileen Dogterom Cees Dekker
author_sort	Siddharth Deshpande
title	Spatiotemporal control of coacervate formation within liposomes
title_short	Spatiotemporal control of coacervate formation within liposomes
title_full	Spatiotemporal control of coacervate formation within liposomes
title_fullStr	Spatiotemporal control of coacervate formation within liposomes
title_full_unstemmed	Spatiotemporal control of coacervate formation within liposomes
title_sort	spatiotemporal control of coacervate formation within liposomes
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-04-01
description	The understanding of liquid-liquid phase separation is crucial to cell biology and benefits from cell-mimicking in vitro assays. Here, the authors develop a microfluidic platform to study coacervate formation inside liposomes and show the potential of these hybrid systems to create synthetic cells.
url	https://doi.org/10.1038/s41467-019-09855-x
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Spatiotemporal control of coacervate formation within liposomes

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