Phosphoinositide 3-kinase signaling in the vertebrate retina

Phosphoinositide 3-kinase signaling in the vertebrate retina

The phosphoinositide (PI) cycle, discovered over 50 years ago by Mabel and Lowell Hokin, describes a series of biochemical reactions that occur on the inner leaflet of the plasma membrane of cells in response to receptor activation by extracellular stimuli. Studies from our laboratory have shown tha...

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Main Author: Raju V.S Rajala
Format: Article
Language:English
Published: Elsevier 2010-01-01
Series:Journal of Lipid Research
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520313729
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spelling doaj-ae4b7a217a59421ab5b77b2862589f132021-04-28T05:57:37ZengElsevierJournal of Lipid Research0022-22752010-01-01511422Phosphoinositide 3-kinase signaling in the vertebrate retinaRaju V.S Rajala0To whom correspondence should be addressed; Departments of Ophthalmology and Cell Biology, and Dean A. McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104The phosphoinositide (PI) cycle, discovered over 50 years ago by Mabel and Lowell Hokin, describes a series of biochemical reactions that occur on the inner leaflet of the plasma membrane of cells in response to receptor activation by extracellular stimuli. Studies from our laboratory have shown that the retina and rod outer segments (ROSs) have active PI metabolism. Biochemical studies revealed that the ROSs contain the enzymes necessary for phosphorylation of phosphoinositides. We showed that light stimulates various components of the PI cycle in the vertebrate ROS, including diacylglycerol kinase, PI synthetase, phosphatidylinositol phosphate kinase, phospholipase C, and phosphoinositide 3-kinase (PI3K). This article describes recent studies on the PI3K-generated PI lipid second messengers in the control and regulation of PI-binding proteins in the vertebrate retina.http://www.sciencedirect.com/science/article/pii/S0022227520313729
collection DOAJ
language English
format Article
sources DOAJ
author Raju V.S Rajala
spellingShingle Raju V.S Rajala
Phosphoinositide 3-kinase signaling in the vertebrate retina
Journal of Lipid Research
author_facet Raju V.S Rajala
author_sort Raju V.S Rajala
title Phosphoinositide 3-kinase signaling in the vertebrate retina
title_short Phosphoinositide 3-kinase signaling in the vertebrate retina
title_full Phosphoinositide 3-kinase signaling in the vertebrate retina
title_fullStr Phosphoinositide 3-kinase signaling in the vertebrate retina
title_full_unstemmed Phosphoinositide 3-kinase signaling in the vertebrate retina
title_sort phosphoinositide 3-kinase signaling in the vertebrate retina
publisher Elsevier
series Journal of Lipid Research
issn 0022-2275
publishDate 2010-01-01
description The phosphoinositide (PI) cycle, discovered over 50 years ago by Mabel and Lowell Hokin, describes a series of biochemical reactions that occur on the inner leaflet of the plasma membrane of cells in response to receptor activation by extracellular stimuli. Studies from our laboratory have shown that the retina and rod outer segments (ROSs) have active PI metabolism. Biochemical studies revealed that the ROSs contain the enzymes necessary for phosphorylation of phosphoinositides. We showed that light stimulates various components of the PI cycle in the vertebrate ROS, including diacylglycerol kinase, PI synthetase, phosphatidylinositol phosphate kinase, phospholipase C, and phosphoinositide 3-kinase (PI3K). This article describes recent studies on the PI3K-generated PI lipid second messengers in the control and regulation of PI-binding proteins in the vertebrate retina.
url http://www.sciencedirect.com/science/article/pii/S0022227520313729
work_keys_str_mv AT rajuvsrajala phosphoinositide3kinasesignalinginthevertebrateretina
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