Preparation, characterization of some transition metal complexes of hydrazone derivatives and their antibacterial and antioxidant activities

• Main Authors: S.A. Aly, S.K. Fathalla
• Format: Article
• Language: English
• Published: Elsevier 2020-02-01
• Series: Arabian Journal of Chemistry
• Online Access: http://www.sciencedirect.com/science/article/pii/S1878535219301777

A new series of metal complexes of Pd(II), Cd(II) and Cu(II, I) of polydentate Schiff base ligand (H2L), namely ((Z)-2-(phenylamino)-N'-(thiophen-2-ylmethylene) acetohydrazide) have been prepared. The ligand and its metal complexes have been characterized based on various physicochemical studies as elemental analyses, molar conductance, spectral (UV–Vis, MS, IR, 1H NMR, 13C NMR and XRD), magnetic moment measurements and thermal studies (TG, DTG). In the view of previous studies, the ligand (H2L) acts as polydentate one and coordinates with metal ions to form all metal complexes. The kinetic and thermodynamic parameters of decomposition process (ΔG, ΔH, ΔS) were calculated. The possible structures of the metal complexes have been computed using the molecular mechanic calculations using the hyper chem. 8.03 molecular modeling program. The calculations are performed to obtain the optimized molecular geometry. The antibacterial study of the selected compounds was assayed against two pathogenic bacteria. Moreover, the complexes (Cu II, I), Cd(II), Pd(II)) and the ligand revealed excellent antioxidant properties and could be useful in fighting the free radicals which occur in close connection with cancerous cells. It was remarkable that the two complexes (Cu II, I) demonstrated stronger antioxidant effects than their parent compounds. It is clear that the new complexes are good active compounds for use in a variety of applications. Keywords: Metal complexes, Thermal behavior, Powder X-ray diffraction, Molecular modeling, Biological activity