Cerebellar mitochondrial dysfunction and concomitant multi-system fatty acid oxidation defects are sufficient to discriminate PTSD-like and resilient male mice

Cerebellar mitochondrial dysfunction and concomitant multi-system fatty acid oxidation defects are sufficient to discriminate PTSD-like and resilient male mice

The impact of trauma on mental health is complex with poorly understood underlying mechanisms. Mitochondrial dysfunction is increasingly implicated in psychopathologies and mood disorders, including post-traumatic stress disorder (PTSD). We hypothesized that defects in mitochondrial energy metabolis...

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Bibliographic Details
Main Authors: Graeme Preston, Tim Emmerzaal, Faisal Kirdar, Laura Schrader, Marloes Henckens, Eva Morava, Tamas Kozicz
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
PTSD
Cerebellum
Mitochondria
Fatty acid oxidation
Resilience
Acetylcarnitine
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354620300697

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