AAV2-mediated and hypoxia response element-directed expression of bFGF in neural stem cells showed therapeutic effects on spinal cord injury in rats

Abstract Neural stem cell (NSCs) transplantation has been one of the hot topics in the repair of spinal cord injury (SCI). Fibroblast growth factor (FGF) is considered a promising nerve injury therapy after SCI. However, owing to a hostile hypoxia condition in SCI, there remains a challenging issue...

Full description

Bibliographic Details
Main Authors: Sipin Zhu, Yibo Ying, Jiahui Ye, Min Chen, Qiuji Wu, Haicheng Dou, Wenfei Ni, Huazi Xu, Jiake Xu
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03546-6