Force-Induced Autophagy in Periodontal Ligament Stem Cells Modulates M1 Macrophage Polarization via AKT Signaling

Force-Induced Autophagy in Periodontal Ligament Stem Cells Modulates M1 Macrophage Polarization via AKT Signaling

Autophagy, a lysosomal degradation pathway, serves as a protective cellular mechanism in maintaining cell and tissue homeostasis under mechanical stimulation. As the mechanosensitive cells, periodontal ligament stem cells (PDLSCs) play an important role in the force-induced inflammatory bone remodel...

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Bibliographic Details
Main Authors: Nan Jiang, Danqing He, Yushi Ma, Junxiang Su, Xiaowen Wu, Shengjie Cui, Zixin Li, Yanheng Zhou, Huajie Yu, Yan Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
autophagy
macrophage polarization
bone remodeling
mechanical force
periodontal ligament stem cells
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.666631/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.666631/full

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