Standardization of the liquid biopsy for pediatric diffuse midline glioma using ddPCR

Standardization of the liquid biopsy for pediatric diffuse midline glioma using ddPCR

Abstract Diffuse midline glioma (DMG) is a highly morbid pediatric brain tumor. Up to 80% of DMGs harbor mutations in histone H3-encoding genes, associated with poor prognosis. We previously showed the feasibility of detecting H3 mutations in circulating tumor DNA (ctDNA) in the liquid biome of chil...

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Bibliographic Details
Main Authors: Daphne Li, Erin R. Bonner, Kyle Wierzbicki, Eshini Panditharatna, Tina Huang, Rishi Lulla, Sabine Mueller, Carl Koschmann, Javad Nazarian, Amanda M. Saratsis
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-84513-1

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