The Long-Lasting Protective Effect of HGF in Cardiomyoblasts Exposed to Doxorubicin Requires a Positive Feed-Forward Loop Mediated by Erk1,2-Timp1-Stat3

The Long-Lasting Protective Effect of HGF in Cardiomyoblasts Exposed to Doxorubicin Requires a Positive Feed-Forward Loop Mediated by Erk1,2-Timp1-Stat3

Previous studies showed that the hepatocyte growth factor (HGF)–Met receptor axis plays long-lasting cardioprotection against doxorubicin anti-cancer therapy. Here, we explored the mechanism(s) underlying the HGF protective effect. DNA damage was monitored by histone H2AX phosphorylation and apoptos...

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Bibliographic Details
Main Authors: Simona Gallo, Martina Spilinga, Elena Casanova, Alessandro Bonzano, Carla Boccaccio, Paolo Maria Comoglio, Tiziana Crepaldi
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
Met receptor
HGF
Erk1,2
Stat3
Timp1
anthracycline
Online Access:https://www.mdpi.com/1422-0067/21/15/5258

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