Characterization of the Clinical Significance of PD-1/PD-Ls Expression and Methylation in Patients With Low-Grade Glioma
Background: Immune checkpoints play crucial roles in the immune escape of cancer cells. However, the exact prognostic values of expression and methylation of programmed-death 1 (PD-1), programmed-death-ligand 1 (PD-L1) and PD-L2 in low-grade glioma (LGG) have not been well-defined yet. Methods: A to...
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doaj-ae1533bd606a4fd3bd94c5c0127785c02021-05-10T03:33:32ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382021-05-012010.1177/15330338211011970Characterization of the Clinical Significance of PD-1/PD-Ls Expression and Methylation in Patients With Low-Grade GliomaJie Mei0Yun Cai1Rui Xu2Xuejing Yang3Weijian Zhou4Huiyu Wang5Chaoying Liu6 Department of Oncology, , Wuxi, China Department of Bioinformatics, , Nanjing, China School of Basic Medical Sciences, , Nanjing, China Department of Oncology, , Wuxi, China Department of Oncology, , Wuxi, China Department of Oncology, , Wuxi, China Department of Oncology, , Wuxi, ChinaBackground: Immune checkpoints play crucial roles in the immune escape of cancer cells. However, the exact prognostic values of expression and methylation of programmed-death 1 (PD-1), programmed-death-ligand 1 (PD-L1) and PD-L2 in low-grade glioma (LGG) have not been well-defined yet. Methods: A total 514 LGG samples from the Cancer Genome Atlas (TCGA) dataset containing gene expression, DNA methylation, and survival data were enrolled in our study. Besides, a total of 137 primary LGG samples from the Chinese Glioma Genome Atlas (CGGA) database were also extracted for the survival analysis of the prognostic values of PD-1/PD-Ls expression. Results: PD-1/PD-Ls had distinct co-expression patterns in LGG tissues. The expression and methylation level of PD-1/PD-Ls seemed to be various in different LGG subtypes. Besides, overexpression and hypo-methylation of PD-1/PD-Ls were associated with worse prognosis. In addition, PD-1/PD-Ls expression was positively associated with TIICs infiltration, while their methylation was negatively associated with TIICs infiltration. Moreover, PD-1/PD-Ls and their positively correlated gene mainly participated in immune response related biological processes. Conclusion: To conclude, overexpression and hypo-methylation of PD-1/PD-Ls predicted unfavorable prognosis in LGG patients, suggesting those patients may benefit from PD1/PD-Ls checkpoint inhibitors treatment.https://doi.org/10.1177/15330338211011970 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jie Mei Yun Cai Rui Xu Xuejing Yang Weijian Zhou Huiyu Wang Chaoying Liu |
spellingShingle |
Jie Mei Yun Cai Rui Xu Xuejing Yang Weijian Zhou Huiyu Wang Chaoying Liu Characterization of the Clinical Significance of PD-1/PD-Ls Expression and Methylation in Patients With Low-Grade Glioma Technology in Cancer Research & Treatment |
author_facet |
Jie Mei Yun Cai Rui Xu Xuejing Yang Weijian Zhou Huiyu Wang Chaoying Liu |
author_sort |
Jie Mei |
title |
Characterization of the Clinical Significance of PD-1/PD-Ls Expression and Methylation in Patients With Low-Grade Glioma |
title_short |
Characterization of the Clinical Significance of PD-1/PD-Ls Expression and Methylation in Patients With Low-Grade Glioma |
title_full |
Characterization of the Clinical Significance of PD-1/PD-Ls Expression and Methylation in Patients With Low-Grade Glioma |
title_fullStr |
Characterization of the Clinical Significance of PD-1/PD-Ls Expression and Methylation in Patients With Low-Grade Glioma |
title_full_unstemmed |
Characterization of the Clinical Significance of PD-1/PD-Ls Expression and Methylation in Patients With Low-Grade Glioma |
title_sort |
characterization of the clinical significance of pd-1/pd-ls expression and methylation in patients with low-grade glioma |
publisher |
SAGE Publishing |
series |
Technology in Cancer Research & Treatment |
issn |
1533-0338 |
publishDate |
2021-05-01 |
description |
Background: Immune checkpoints play crucial roles in the immune escape of cancer cells. However, the exact prognostic values of expression and methylation of programmed-death 1 (PD-1), programmed-death-ligand 1 (PD-L1) and PD-L2 in low-grade glioma (LGG) have not been well-defined yet. Methods: A total 514 LGG samples from the Cancer Genome Atlas (TCGA) dataset containing gene expression, DNA methylation, and survival data were enrolled in our study. Besides, a total of 137 primary LGG samples from the Chinese Glioma Genome Atlas (CGGA) database were also extracted for the survival analysis of the prognostic values of PD-1/PD-Ls expression. Results: PD-1/PD-Ls had distinct co-expression patterns in LGG tissues. The expression and methylation level of PD-1/PD-Ls seemed to be various in different LGG subtypes. Besides, overexpression and hypo-methylation of PD-1/PD-Ls were associated with worse prognosis. In addition, PD-1/PD-Ls expression was positively associated with TIICs infiltration, while their methylation was negatively associated with TIICs infiltration. Moreover, PD-1/PD-Ls and their positively correlated gene mainly participated in immune response related biological processes. Conclusion: To conclude, overexpression and hypo-methylation of PD-1/PD-Ls predicted unfavorable prognosis in LGG patients, suggesting those patients may benefit from PD1/PD-Ls checkpoint inhibitors treatment. |
url |
https://doi.org/10.1177/15330338211011970 |
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