Upregulated TRAIL and Reduced DcR2 Mediate Apoptosis of Decidual PMN-MDSC in Unexplained Recurrent Pregnancy Loss

Upregulated TRAIL and Reduced DcR2 Mediate Apoptosis of Decidual PMN-MDSC in Unexplained Recurrent Pregnancy Loss

Myeloid-derived suppressor cells (MDSC), especially polymorphonuclear MDSC (PMN-MDSC), accumulate in maternal-fetal interface during pregnancy and are involved in the maintenance of immune tolerance. Decreased PMN-MDSC is associated with pregnancy complications such as unexplained recurrent pregnanc...

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Bibliographic Details
Main Authors: Congcong Li, Xiaoxin Zhang, Xiaomin Kang, Chao Chen, Feng Guo, Qiaohong Wang, Aimin Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
polymorphonuclear myeloid-derived suppressor cell
TRAIL
TRAIL receptor
apoptosis
unexplained recurrent pregnancy loss
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01345/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01345/full

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